Document Detail


Rhinal cortex asymmetries in patients with mesial temporal sclerosis.
MedLine Citation:
PMID:  17764980     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The rhinal cortex, comprising the entorhinal (ErC) and perirhinal (PrC) cortices, is one component of the limbic system that may be affected in patients with epilepsy and other temporal lobe pathologies. This study extended quantitative examination of the limbic system through development and validation of volumetric protocols to measure the ErC and PrC.
METHODS: Volumes were calculated from MRI studies using ANALYZE 7.5 and based on detailed anatomical definitions developed for the study. Subjects were 61 temporal lobe epilepsy patients with mesial temporal sclerosis (MTS: 33 left, 28 right) and 20 neurologically normal controls. Inter-rater reliabilities for the ErC and PrC volume protocols were found to be high (range 0.86-0.92).
RESULTS: Ipsilateral hippocampal volume was reduced in patients with MTS, while contralateral volume did not differ significantly from controls. In the patients, rhinal cortex volumes were reduced as a function of laterality of disease. The pattern of correlations between ErC and PrC differed between disease groups. Hippocampal and rhinal cortex volumes were not significantly correlated. A significant four-way interaction was found between side of MTS, hemisphere, structure and handedness.
CONCLUSIONS: This quantitative study demonstrates reliable in vivo evidence of morphometric changes in ErC and PrC in a substantial number of patients with unilateral MTS. The relationship observed between handedness, structure and disease status may suggest a role for cerebral dominance in modulating the expression of MTS.
Authors:
Catherine E Meade; Stephen C Bowden; Greg Whelan; Mark J Cook
Publication Detail:
Type:  Journal Article     Date:  2007-08-30
Journal Detail:
Title:  Seizure     Volume:  17     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-06-24     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  234-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Atrophy / complications,  pathology,  physiopathology
Entorhinal Cortex / pathology*
Epilepsy, Temporal Lobe / complications,  pathology,  physiopathology*
Female
Functional Laterality / physiology*
Hippocampus / pathology
Humans
Magnetic Resonance Imaging
Male
Sclerosis / complications,  pathology,  physiopathology
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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