Document Detail

Rheumatologic manifestations of hepatic diseases.
MedLine Citation:
PMID:  14599926     Owner:  NLM     Status:  MEDLINE    
A possible link is suggested between hepatic diseases and rheumatic disease. Polyarthralgia and polyarthritis may be seen during the prodromal period of acute viral hepatitis, especially in hepatitis B virus (HBV). The symptoms of arthritis, mild, localized or generalized, mostly involve the small joints of hands. Joint symptoms frequently precede the onset of jaundice, no residual joint deformities. Circulating immune complexes are believed to play a causative role in the development of vasculitis and arthritis. Hemochromatosis is an antosomal recessive disorder of iron. About 43%-81% of patients with hemochromatosis have arthritis. The common extrahepatic manifestations of autoimmune hepatitis are arthralgia and skin rash. The reported prevalence of symptomatic inflammatory arthropathy in patients with primary biliary cirrhosis ranges from 4% to 50%. Skeletal involvement with Wilson's disease is common. Such patients may complain of pain and stiffness, mainly in the knee, wrist, or other large joints. Shwachman's syndrome is a disorder of pancreatic exocrine. Symmetric bone lesions have been reported in 10% to 15% of patients. They are involved predominantly at the femoral neck. Rheumatic symptoms are seen in one third of adult patients with cystic fibrosis and arthritis in 2.5% to 12% of patients. The arthritis caused by pancreatic panniculitis is usually symmetrical and involves the small joints of the hand, wrist, and feet, but may involve such larger joints as the elbow, ankle, and knee.
Zhao-Chun Chi; Su-Zhen Ma
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  2     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-01-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Division of Gastroenterology, Department of Medicine, People's Hospital, Qingdao 266001, China.
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MeSH Terms
Liver Diseases / complications*,  immunology
Pancreatic Diseases / complications,  immunology
Rheumatic Diseases / etiology*,  immunology

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