| Rheumatoid factor measurement-continuing problems 70 years after discovery. | |
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MedLine Citation:
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PMID: 21455659 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There have been long-standing unpublished differences in rheumatoid factor (RF) results, based on the Royal College of Pathologists of Australasia external quality assurance program. This study compared RF results between two commonly used commercial instruments. Serum samples were exchanged between a laboratory using a Beckman Immage immunonephelometer and another using a Roche Modular immunoturbidimeter. The World Health Organization (WHO) reference standard for RF (W1066) was then used to compare the two methods. The Roche immunoturbidimeter appears to have superior sensitivity. Furthermore, there is significant bias between the two instruments as levels of RF increase. Results from the WHO RF reference preparation correlated most closely with the results from the Roche immunoturbidimeter. Standardization for RF measurement is not optimal and has not been achieved between these two commonly used instruments. This may have clinical implications for patient management. |
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Authors:
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Rohan Ameratunga; Samarina Musaad; Claudia Sugrue; Campbell Kyle |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-1 |
Journal Detail:
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Title: Clinical rheumatology Volume: - ISSN: 1434-9949 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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LabPlus, Auckland Hospital, Park Rd, Grafton, Auckland, 1010, New Zealand, rohana@adhb.govt.nz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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