Document Detail

Rheumatoid factor isotypes and renal disease in systemic lupus erythematosus.
MedLine Citation:
PMID:  3685907     Owner:  NLM     Status:  MEDLINE    
There is no agreement on whether rheumatoid factor (RF) exerts protection, injury, or is an epiphenomenon with regard to kidney disease in systemic lupus erythematosus (SLE). In this study we examined the occurrence and isotype distribution of rheumatoid factor in SLE in relation to some clinical parameters, including renal function and arthritis. A highly significant correlation (p less than 0.001) was noted between the presence of IgG RF and absence of kidney disease. The IgG RF also seemed to protect SLE patients from developing arthritis (p less than 0.01). On the other hand, elevated IgM RF levels indicated active SLE disease. The results obtained are discussed in relation to the ability of RF to interact with immune complexes in vitro and in vivo.
A Tarkowski; G Westberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  16     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-21     Completed Date:  1988-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  309-12     Citation Subset:  IM    
Department of Medical Microbiology, Sahlgrenska Sjukhuset, University of Göteborg, Sweden.
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MeSH Terms
Arthritis / immunology*
Immunoglobulin G / immunology*
Immunoglobulin Isotypes / immunology*
Lupus Erythematosus, Systemic / immunology*
Lupus Nephritis / immunology*
Rheumatoid Factor / immunology*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin Isotypes; 9009-79-4/Rheumatoid Factor

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