Document Detail

Rheumatoid arthritis and multiple sclerosis in the same patient. Two case-reports.
MedLine Citation:
PMID:  10327497     Owner:  NLM     Status:  MEDLINE    
We report on two new patients with both rheumatoid arthritis and multiple sclerosis. In one patient, the first manifestations of multiple sclerosis occurred eight years after onset of seronegative rheumatoid arthritis without extraarticular manifestations. The other patient had a 20-year history of multiple sclerosis when she developed seropositive, nodular rheumatoid arthritis. Neither patient had evidence of systemic lupus erythematosus. A lip biopsy was done in one patient, with normal results; the other patient was free of clinical symptoms of sicca syndrome and had a negative Schirmer's test. The paucity of similar cases in the literature is surprising since multiple sclerosis and rheumatoid arthritis are both autoimmune diseases and share many pathophysiologic and etiologic features. Although chance alone may explain the occurrence of both conditions in the same patient, the existence of shared etiologic factors should in theory increase the likelihood of the association.
H Attout; E Toussirot; B Augé; D Chavot; D Wendling
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Revue du rhumatisme (English ed.)     Volume:  66     ISSN:  1169-8446     ISO Abbreviation:  Rev Rhum Engl Ed     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-08-06     Completed Date:  1999-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313916     Medline TA:  Rev Rhum Engl Ed     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Rheumatology Department, J. Minjoz Teaching Hospital, Besançon, France.
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MeSH Terms
Arthritis, Rheumatoid / complications*,  immunology
Middle Aged
Multiple Sclerosis / complications*,  immunology

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