Document Detail


Rheumatoid arthritis induced by alpha-interferon therapy.
MedLine Citation:
PMID:  11529644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interferon (IFN) therapy has been used for the treatment of common diseases such as hepatitis C, myeloproliferative disorders, autoimmune diseases and various types of cancer. Given the biological properties of interferon, it is not surprising that there are a larger number of side effects due to its use. Although rheumatoid arthritis (RA) is one of the most common autoimmune diseases found in clinical practice, it does not seem to be frequently related to IFN therapy. We report a 40-year-old female patient who, after high doses of IFN-alpha therapy for malignant melanoma, developed symmetrical polyarthritis, with pain and oedema in small and large joints, associated with prolonged morning stiffness. She had positive rheumatoid factor and DR4 HLA phenotype. She was treated with deflazacort (6 mg/day), chloroquine and NSAIDs, with a partial response. In conclusion, although the development of RA after IFN therapy is a rare event, IFN may work as a 'trigger' for such complication, leading to deregulation in the immune cascade in a person genetically predisposed.
Authors:
E Passos de Souza; P T Evangelista Segundo; F F José; D Lemaire; M Santiago
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  20     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-31     Completed Date:  2002-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  297-9     Citation Subset:  IM    
Affiliation:
Universidade Federal da Bahia, Salvador, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Arthritis, Rheumatoid / chemically induced*,  drug therapy,  physiopathology
Chloroquine / administration & dosage
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Interferon-alpha / administration & dosage,  adverse effects*
Melanoma / diagnosis,  drug therapy*
Severity of Illness Index
Skin Neoplasms / diagnosis,  drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Interferon-alpha; 54-05-7/Chloroquine

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