Document Detail

Rheumatoid arthritis and erythema multiforme: a possible pathogenetic link for T-cell-mediated autoimmune and reactive skin diseases?
MedLine Citation:
PMID:  24183223     Owner:  NLM     Status:  In-Data-Review    
We present a case of a woman with a 14-year history of rheumatoid arthritis, who showed simultaneously and gradually appearing, annular, erythematous, itchy patches and exacerbation of the joint symptoms, of one month duration, after pregnancy. Clinical and histologic features led us to the diagnosis of erythema multiforme. While it is not possible to exclude that the co-occurrence of the two conditions is coincidental, our case suggests the possibility that erythema multiforme is a sign of an ample alteration of the immune system that may occur in patients with systemic immune diseases as a consequence of the action of various triggering factors, such as molecular mimicry between endogenous and exogenous antigens or pregnancy, which is notoriously a period of complex and still largely unexplored alterations in the immune system reactivity.
Mario Vaccaro; Fabrizio Guarneri; Olga Barbuzza; Serafinella P Cannavo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermatovenerologica Croatica : ADC     Volume:  21     ISSN:  1847-6538     ISO Abbreviation:  Acta Dermatovenerol Croat     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-11-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433781     Medline TA:  Acta Dermatovenerol Croat     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  IM    
Mario Vaccaro, MD, PhD, University of Messina, Department of Clinical and Experimental Medicine - Dermatology, Via Consolare Valeria, 1 - Gazzi, 98125 Messina, Italy;
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