| Rheumatic manifestations of diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 21092846 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
DM is associated with various musculoskeletal manifestations. The strength of this relationship varies among the various musculoskeletal disorders; the associations are based mostly on epidemiologic data. For most of these conditions, definitive pathophysiologic correlates are lacking.Hand and shoulder disorders occur more frequently than other musculoskeletal manifestations of DM. Recognition of the association between DM and shoulder adhesive capsulitis, DD, and stenosing flexor tenosynovitis facilitates their correct diagnosis in the setting of DM and prompt initiation of appropriate treatment, which may include optimizing glycemic control. Conversely, awareness and identification of the characteristic musculoskeletal manifestations of DM may facilitate earlier diagnosis of DM and initiation of glucose-lowering therapy to retard the development of diabetic complications.Much less has been published about the musculoskeletal complications of DM than about its micro- and macrovascular complications. Prospective case-control cohort studies are needed to establish the true prevalence of musculoskeletal complications of DM and the metabolic syndrome, especially in this era of tighter glycemic control.The potential relationship between DM and the development of OA needs to be clarified in large, prospective, case-control cohort studies. The effect on musculoskeletal manifestations of various therapeutic regimens to manage DM should be studied prospectively. Treatment regimens for some musculoskeletal conditions associated with DM, such as DISH, should be studied in larger prospective, randomized,controlled clinical trials.At the molecular level, further studies are warranted to clarify the potential contribution of AGEs and adipokines to the development of OA and diabetic musculoskeletal syndromes, such as shoulder adhesive capsulitis, DD, stenosing flexor tenosynovitis, and LJM. Identification of such molecular targets for therapy would promote the development of additional treatments for these and other rheumatic diseases. |
| | |
Authors:
|
Dorota Lebiedz-Odrobina; Jonathan Kay |
Related Documents
:
|
18533366 - Methylglyoxal, diabetes mellitus and diabetic complications. 11902636 - Education of patients and use of insulin pumps in diabetic treatment. 19148376 - The prevalence of chronic diabetic complications and metabolic syndrome is not associat... 16472176 - Towards newer molecular targets for chronic diabetic complications. 15070936 - Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained... 10542046 - Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Rheumatic diseases clinics of North America Volume: 36 ISSN: 1558-3163 ISO Abbreviation: Rheum. Dis. Clin. North Am. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8708093 Medline TA: Rheum Dis Clin North Am Country: United States |
Other Details:
|
Languages: eng Pagination: 681-99 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Rheumatology Division, Department of Medicine, University of Massachusetts School of Medicine, 55 Lake Avenue North, Worcester, MA 01655, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Osteoporosis and osteomalacia.
Next Document: Adrenal disorders in rheumatology.