Document Detail

Rheumatic fever and rubella immunity.
MedLine Citation:
PMID:  2134095     Owner:  NLM     Status:  MEDLINE    
Anti-rubella IgG titer was estimated in 106 children: sixty five had acute rheumatic fever and 41 had either a history of rheumatic fever or a definite rheumatic heart disease. Their ages ranged from 6 to 16 years old (11.4 +/- 2.7 years). Sixty two were females and 44 were males. They were compared with 35 control normal subjects of both sexes with no history of rheumatic affection, aged 5 to 14 years (10.2 +/- 3.6 years). The results obtained showed a significantly (p less than 0.001) higher rubella IgG titer level in the controls (1066.5 +/- 8.3) as compared to the rheumatic cases (521.2 +/- 3.0). No differences were found in the rubella antibody titer between cases of acute rheumatic fever and those with history of rheumatic fever or rheumatic heart disease, nor between males and females in either cases or controls. We suggested that the low rubella IgG levels encountered in the rheumatic cases, make them more susceptible to rheumatic fever affection. In other words, a high immunity level against rubella might also produce an immunity against an agent, possibly related to rubella virus, with a specific role in the development of rheumatic fever. Vaccination against rubella could be worth a trial, for prevention of rheumatic fever.
M el-Kholy; M Helmy; M Shaker; H Lotfi; M Gadalla; M Darwish; A K Khattab
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Egyptian Public Health Association     Volume:  65     ISSN:  0013-2446     ISO Abbreviation:  J Egypt Public Health Assoc     Publication Date:  1990  
Date Detail:
Created Date:  1992-04-16     Completed Date:  1992-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505602     Medline TA:  J Egypt Public Health Assoc     Country:  EGYPT    
Other Details:
Languages:  eng     Pagination:  609-16     Citation Subset:  IM    
Pediatric Department, Ain Shams University, Cairo, Egypt.
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MeSH Terms
Antibodies, Viral / blood*
Egypt / epidemiology
Hospitals, University
Immunoglobulin G / immunology*
Rheumatic Fever / blood*
Rubella / epidemiology,  immunology*
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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