Document Detail

Rhesus disease: postnatal management and outcome.
MedLine Citation:
PMID:  10485296     Owner:  NLM     Status:  MEDLINE    
The incidence of rhesus haemolytic disease has been markedly reduced. Affected infants who have had intrauterine transfusions suffer a late hyporegenerative anaemia. Postnatal haemolysis and hence treatment for hyperbilirubinaemia is less commonly needed. Optimal phototherapy reduces the need for postnatal exchange transfusions, but data on the efficacy of inhibitors of bilirubin production such as haem oxygenase inhibitors or immunoglobulin are less secure. Even hydropic infants have less than 20% mortality and bilirubin encephalopathy is uncommon. There is, however, very limited information on the long-term outcome of infants with rhesus haemolytic disease. Multicentre collaboration is required to test strategies to improve the management of affected individuals further and to provide meaningful data on their prognosis.
A Greenough
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of pediatrics     Volume:  158     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  689-93     Citation Subset:  IM    
Children Nationwide Regional Neonatal Intensive Care Centre, King's College Hospital, London, UK.
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MeSH Terms
Blood Transfusion
Blood Transfusion, Intrauterine
Immunoglobulins, Intravenous / therapeutic use
Infant, Newborn
Rh Isoimmunization / complications,  mortality,  therapy*
Reg. No./Substance:
0/Immunoglobulins, Intravenous

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