| Rhesus Monkey TRIM5α Has Distinct HIV-1 Restriction Activity Among Different Mammalian Cell Lines. | |
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MedLine Citation:
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PMID: 21947260 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rhesus monkey TRIM5α (TRIM5α(rh)), a member of the tripartite motif (TRIM) family, was identified as the main restriction factor responsible for resistance of old world monkey cells to HIV-1 infection. However, the precise mechanism of HIV-1 infection inhibition by TRIM5α remains elusive and appears to be related to some cellular cofactors. Here we reported that TRIM5α(rh) can significantly reduce the infection efficiency of VSV-G pseudotyped HIV-1/MA-YFP virus in human epithelial carcinoma (HeLa) cells, moderately reduce in porcine kidney (PK-15) cells and have no effect on the pseudotyped virus infection in Madin-Darby canine kidney (MDCK) cells. Furthermore, we found that the different HIV-1 restriction activities have no relation with the intracellular localization of TRIM5α(rh). These results indicate that the cellular environment is very important for the efficient anti-HIV-1 activity of TRIM5α(rh). We speculate that some unknown factors required for HIV-1 infection inhibition activity are adequately expressed in HeLa cells, inadequately expressed in PK-15 cells and absent in MDCK cells. |
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Authors:
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Jian Gong; Xi-Hui Shen; Hui Qiu; Chao Chen; Rong-Ge Yang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-24 |
Journal Detail:
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Title: Current microbiology Volume: - ISSN: 1432-0991 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7808448 Medline TA: Curr Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Xiaohongshan 44, Wuhan, 430071, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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