Document Detail

Rheology of sickle cells and its role in microcirculatory dynamics.
MedLine Citation:
PMID:  3615484     Owner:  NLM     Status:  MEDLINE    
The alterations in the viscoelastic properties of the hemoglobin S solution following deoxygenation can be correlated, on the one hand, with the gelation of the HbS molecules and, on the other hand, with changes in the rheological behavior of the deoxygenated SS erythrocytes. The abnormal rheology of SS erythrocytes forms the basis of their altered flow behavior through filter pores in vitro and microcirculation in vivo. The results support the notion that the rheological behavior of sickle cells is an important link between the molecular events in hemoglobin S following deoxygenation and the behavior of the cell in the microcirculation. Although recent advances have shed considerable lights on the rheology of sickle cells in a variety of conditions, further studies are needed in order to elucidate the pathophysiological role of cell rheology in this disease, especially in terms of the influence of individual SS cells in the heterogeneous populations and the correlation between in vitro and in vivo behavior of SS cells.
S Chien; A A Kaperonis; R G King; H H Lipowsky; E A Schmalzer; L A Sung; K L Sung; S Usami
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  240     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-08     Completed Date:  1987-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  151-65     Citation Subset:  IM    
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MeSH Terms
Anemia, Sickle Cell / blood,  physiopathology*
Blood Viscosity
Erythrocytes / physiology*
Microcirculation / physiopathology
Grant Support

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