Document Detail


Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel.
MedLine Citation:
PMID:  24865937     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Viscoelasticity is a useful parameter for characterizing the intrinsic properties of the cross-linked polyacrylate hydrogel used in cataplasm bases. The aim of this study was to investigate the effects of various formulation parameters on the rheological characteristics of polyacrylate hydrogel. The hydrogel layers were formed using a partially neutralized polyacrylate (Viscomate(™)), which contained acrylic acid and sodium acrylate in different copolymerization ratios, as the cross-linked gel framework. Dihydroxyaluminum aminoacetate (DAAA), which produces aluminum ions, was used as the cross-linking agent. Rheological analyses were performed using a "stress amplitude sweep" and a "frequency sweep". The results showed that greater amounts of acrylic acid in the structure of Viscomate as well as higher concentrations of DAAA and Viscomate led to an increase in the elastic modulus (G'). However, greater amounts of acrylic acid in the structure of Viscomate and higher concentrations of DAAA had an opposite on the viscous modulus (G″); this might be owing to higher steric hindrance. The results of this study can serve as guidelines for the optimization of formulations for cataplasms.
Authors:
Jian Wang; Hongqin Zhang; Dianyun An; Jian Yu; Wei Li; Teng Shen; Jianxin Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-29
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  -     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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