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Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling.
MedLine Citation:
PMID:  23049539     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine. However, the components of Rheum palmatum that play the antiobesity role are still uncertain. Here, we tested the weight-reducing effect of two major Rheum palmatum compounds on db/db mouse. We found that rhein (100 mg kg(-1) day(-1)), but not emodin, reduced the fat weight in db/db mouse. Using diet-induced obese (DIO) C57BL/6 mice, we identified that rhein blocked high-fat diet-induced obesity, decreased fat mass and the size of white and brown adipocytes, and lowered serum cholesterol, LDL cholesterol, and fasting blood glucose levels in the mice. To elucidate the underlying mechanisms, we used reporter assay and gene expression analysis and found that rhein inhibited peroxisome proliferator-activated receptor γ (PPARγ) transactivity and the expression of its target genes, suggesting that rhein may act as a PPARγ antagonist. Our data indicate that rhein may be a promising choice for antiobesity therapy.
Authors:
Yu Zhang; Shengjie Fan; Na Hu; Ming Gu; Chunxiao Chu; Yiming Li; Xiong Lu; Cheng Huang
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Publication Detail:
Type:  Journal Article     Date:  2012-09-25
Journal Detail:
Title:  PPAR research     Volume:  2012     ISSN:  1687-4765     ISO Abbreviation:  PPAR Res     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2012-10-11     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101269101     Medline TA:  PPAR Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374936     Citation Subset:  -    
Affiliation:
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
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