Document Detail

Rhabdomyosarcoma mimicking acute leukemia in an adult: report of a case with histologic, flow cytometric, cytogenetic, immunohistochemical, and ultrastructural studies.
MedLine Citation:
PMID:  9648909     Owner:  NLM     Status:  MEDLINE    
A case of a 25-year-old man who presented with low back, knee, and hip pain with bruising, leukocytosis, and thrombocytopenia is reported. Histopathologic and flow cytometric studies revealed a malignant neoplasm, which was thought to be consistent with an unusual type of acute leukemia. Subsequent immunohistochemical studies revealed diffuse bone marrow involvement by rhabdomyosarcoma, demonstrated by positivity for desmin and muscle-specific actin. In addition, the diagnosis of metastatic rhabdomyosarcoma was confirmed with cytogenetic and ultrastructural studies. The incidence of rhabdomyosarcoma, a disease usually seen in childhood, presenting with extensive bone marrow involvement and mimicking acute leukemia in an adult is extremely rare. This case highlights the need to consider rhabdomyosarcoma in the differential diagnosis in patients who present with a leukemic picture and atypical blasts that lack the usual hematopoietic markers.
D G Kahn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  122     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-10     Completed Date:  1998-07-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-8     Citation Subset:  AIM; IM    
Department of Pathology, Olive View-University of California, Los Angeles, Medical Center, Sylmar, USA.
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MeSH Terms
Actins / analysis
Bone Marrow / pathology
Desmin / analysis
Diagnosis, Differential
Flow Cytometry
Leukemia, Myeloid, Acute*
Microscopy, Electron
Rhabdomyosarcoma / diagnosis*,  genetics,  pathology
Reg. No./Substance:
0/Actins; 0/Desmin
Comment In:
Arch Pathol Lab Med. 1998 Dec;122(12):1047   [PMID:  9870849 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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