Document Detail

Rhabdomyosarcoma of the breast: a clinicopathologic study and review of the literature.
MedLine Citation:
PMID:  22882949     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Rhabdomyosarcoma (RMS) is an uncommon malignancy of the breast. The aim of this study was to summarize its clinicopathologic features and biological behavior.
METHODS: Five primary or secondary breast RMSs were collected. Their clinicopathological characteristics and all published literature about breast RMS were reviewed. Immunohistochemical study of desmin, myogenic differentiation 1 (MyoD1), myogenin, leukocyte common antigen (LCA), vimentin, cytokeratin (AE1/AE3), E-cadherin, neuron specific enolase (NSE), CD99, chorioallantoic membrane 5.2 (CAM5.2) and epithelial membrane antigen (EMA) expression were performed.
RESULTS: The five patients were all female with ages ranging from 16 to 46 years old (mean, 30 years). Three were metastatic breast RMSs, two embryonal and one solid variant alveolar, with the primary tumor sites the right labium majus, left nasal meatus and nasopharynx, respectively. The other two, one embryonal and one alveolar, were primaries. Grossly, the surgical specimens revealed round or oval, well-demarcated but nonencapsulated masses. Their cut surfaces consisted of homogeneous grayish yellow or white tissue. Microscopically, most tumor cells were poorly differentiated small round, oval or small polygons with eosinophilic cytoplasm. All cases were positive for vimentin, desmin, MyoD1 and myogenin. One embryonal RMS also had a few cells with perinuclear staining of AE1/AE3. The other markers were negative.
CONCLUSIONS: Although primary or metastatic RMS in breast was almost confined to young adolescent females, our cases suggested that it can also happen to the middle-aged women. Embryonal RMS has a certain metastatic potential. MyoD1 and myogenin are two useful markers when making differential diagnosis. Axillary lymph node status and age may play a role in the prognosis of primary breast RMS patients.
Da-Li Li; Ruo-Ji Zhou; Wen-Tao Yang; Jian Wang; Xiao-Hong Yao; Yu-Fan Cheng; Da-Ren Shi
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Chinese medical journal     Volume:  125     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-01-02     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  2618-22     Citation Subset:  IM    
Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China.
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MeSH Terms
Breast Neoplasms / diagnosis*,  metabolism
Middle Aged
Rhabdomyosarcoma / diagnosis*,  metabolism
Young Adult
Comment In:
Chin Med J (Engl). 2013 Mar;126(5):998   [PMID:  23489824 ]

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