Document Detail

Rhabdomyosarcoma of the bladder and prostate in children.
MedLine Citation:
PMID:  1943114     Owner:  NLM     Status:  MEDLINE    
Fifteen children, 14 males and 1 female with a mean age of 4.9 years, were treated for rhabdomyosarcoma of the bladder and the prostate, between 1976 and 1985. In 14 patients, the disease was limited to the pelvis, while one had pulmonary metastases. The lesions were trigonal in 12 patients and involved the prostate in the other three. Eleven patients received vincristine-Adriamycin-cyclophosphamide (VAC) chemotherapy, followed by radiation therapy. Four of these 11 patients required cystoprostatectomy for residual or persistent disease. Of the remaining four patients, two underwent radical cystoprostatectomy, one partial cystectomy and the patient with pulmonary metastases received only chemotherapy. Six patients were alive at 5 years (40% 5-year survival). Six patients died of local relapse within 18 months, one patient died of an unknown cause, while two patients were lost to follow-up free of disease after 2 years.
M R Kamat; J N Kulkarni; H B Tongaonkar; R Ravi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  48     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-11-27     Completed Date:  1991-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  180-2     Citation Subset:  IM    
Department of Uro-Oncology, Tata Memorial Hospital, Bombay, India.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Child, Preschool
Combined Modality Therapy
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Prostatic Neoplasms / mortality,  therapy*
Rhabdomyosarcoma / mortality,  therapy*
Survival Analysis
Urinary Bladder Neoplasms / mortality,  therapy*
Vincristine / administration & dosage
Reg. No./Substance:
0/CAV protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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