Document Detail


Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity.
MedLine Citation:
PMID:  14755734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stiff-Man syndrome (SMS) is a rare disease of the central nervous system characterized by chronic muscle rigidity and autoimmunity directed against synaptic antigens. In a subset of patients, generally positive for antiamphiphysin autoantibodies, SMS has an autoimmune paraneoplastic origin. Amphiphysin isoforms are expressed at high levels in brain and skeletal muscle and often are overexpressed in breast cancer. We report here the occurrence of rhabdomyolysis in a patient with SMS, breast cancer, and antibodies that recognize both brain and muscle amphiphysin isoforms. Immunotherapy induced a remission of both rhabdomyolysis and SMS symptoms. Autoimmune rhabdomyolysis may represent a paraneoplastic complication of cancer patients with amphiphysin autoimmunity.
Authors:
Gabor C Petzold; Melissa Marcucci; Margaret H Butler; Frank K H van Landeghem; Karl M Einhäupl; Michele Solimena; José M Valdueza; Pietro De Camilli
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  55     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-02     Completed Date:  2004-03-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  286-90     Citation Subset:  IM    
Affiliation:
Department of Neurology, Charité Hospital, Humboldt University, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoantibodies / blood
Autoimmunity*
Blotting, Western
Breast Neoplasms / complications,  physiopathology
CHO Cells
Cricetinae
Female
Fluorescent Antibody Technique
Humans
Immunoglobulins / therapeutic use
Middle Aged
Muscle, Skeletal / immunology,  pathology
Nerve Tissue Proteins / immunology*
Paraneoplastic Syndromes / drug therapy,  immunology*
Rhabdomyolysis / complications,  drug therapy,  immunology*
Spinal Cord / pathology
Stiff-Person Syndrome / complications,  drug therapy,  immunology*
Grant Support
ID/Acronym/Agency:
CA46128/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulins; 0/Nerve Tissue Proteins; 147954-52-7/amphiphysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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