Document Detail


Rhabdomyolysis associated with the nutritional supplement Hydroxycut.
MedLine Citation:
PMID:  19139478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: A case of rhabdomyolysis associated with the use of Hydroxycut is reported. SUMMARY: An 18-year-old Caucasian man arrived at an urgent care center complaining of bilateral leg pain and weakness. His creatine kinase (CK) concentration was 13,220 IU/L. He was diagnosed with rhabdomyolysis and instructed to go to the emergency room. He admitted to decreased urine output for four to five days before hospital admission. He had no significant past medical history, and his medications before symptom onset included Hydroxycut four caplets by mouth daily, naproxen sodium 220 mg by mouth as needed for pain, dextroamphetamine saccharate-amphetamine salts (Adderall) 15 mg by mouth once five days prior for a school examination, and hydrocodone-acetaminophen and cyclobenzaprine for pain. His social history revealed a recent increase in his exercise regimen, and his last alcoholic beverage was consumed five days prior. Upon admission, laboratory tests revealed elevated concentrations of CK, serum creatinine (SCr), aspartate transaminase, alanine transaminase (ALT), and alkaline phosphatase. The patient was diagnosed with rhabdomyolysis and treated with intravenous hydration. The patient's leg tenderness was reduced, and he was discharged with instructions to stop Hydroxycut, increase fluid intake, avoid alcohol consumption, and limit physical activity for the next week. Two weeks after hospital discharge, the patient's CK and liver enzyme values returned to normal, excluding ALT and SCr, which remained slightly elevated, and his lower-extremity tenderness fully resolved. CONCLUSION: An 18-year-old Caucasian man with no significant medical history developed rhabdomyolysis possibly associated with the ingestion of Hydroxycut in addition to his increased exercise regimen.
Authors:
Sarah Dehoney; Marlea Wellein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists     Volume:  66     ISSN:  1535-2900     ISO Abbreviation:  Am J Health Syst Pharm     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-06-15     Revised Date:  2009-06-19    
Medline Journal Info:
Nlm Unique ID:  9503023     Medline TA:  Am J Health Syst Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacy Services, University of Utah, Salt Lake City, UT 84132, USA. sarah.dehoney@hsc.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Dietary Supplements / adverse effects*
Fluid Therapy / methods
Humans
Male
Plant Preparations / adverse effects*
Rhabdomyolysis / chemically induced*,  diagnosis*,  therapy
Chemical
Reg. No./Substance:
0/Plant Preparations; 0/hydroxycut
Comments/Corrections
Erratum In:
Am J Health Syst Pharm. 2009 Feb 15;66(4):328
Note: Dosage error in article text

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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