Document Detail


Rhabdomyolysis among acute human poisoning cases.
MedLine Citation:
PMID:  17884958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rhabdomyolysis is a clinical and biochemical syndrome occurring when skeletal muscle cells erupt and result in release of creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and myoglobin into the interstitial space and plasma. Mechanical trauma, compression, excessive muscle activity and ischemia are frequent causes, but non-traumatic rhabdomyolysis is usually caused by a toxic reaction to drugs. In this study, 181 patients suspected of rhabdomyolysis were admitted to the poisoning center of Loghman-Hakim Hospital in Tehran during one year (September 2004 to September 2005) were studied. Patients were included on the basis of physical examination and blood analysis for CPK and LDH. Rhabdomyolysis was confirmed if CPK level has been greater than 975 U/L. Out of 181 patients, 64 were female and 117 were male with an age range between 13-78 years. One-hundred and forty-three (79%) patients had CPK greater than 975 U/L. In 6% of the cases, multiple drug poisoning were observed. Two patients (1.1%) had muscle pain, five patients (2.8%) had rigidity and five patients (2.8%) had muscle inflammation. One-hundred and nineteen patients (65.7%) were febrile. The most common cause of rhabdomyolysis was opium. Blood ALT showed an increase in 109 patients (60.9%), AST in 80 patients (44.7%), and LDH in 144 patients (79.6%). Fifty patients (28.2%) had higher blood direct bilirubin and 64 patients (36.4%) showed higher total bilirubin. Six percent of patients had been diagnosed as ARF by indication of creatinine greater than 1.4 mg/dL. Five percent of patients had hypernatremia and 1.1% of patients had hyperkalemia. It is concluded that rhabdomyolysis is a matter of concern in human poisonings and needs special approach to attend.
Authors:
H Talaie; A Pajouhmand; M Abdollahi; R Panahandeh; H Emami; S Hajinasrolah; M Tghaddosinezhad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  26     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-09-21     Completed Date:  2007-10-18     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-61     Citation Subset:  IM    
Affiliation:
Toxicological Research Center, Loghman-Hakim Hospital, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Bilirubin / blood
Creatine Kinase / blood*
Female
Humans
Incidence
Iran / epidemiology
L-Lactate Dehydrogenase / blood*
Male
Middle Aged
Poison Control Centers / statistics & numerical data
Poisoning / blood,  complications*,  enzymology,  epidemiology
Rhabdomyolysis / blood,  enzymology,  epidemiology,  etiology*
Chemical
Reg. No./Substance:
635-65-4/Bilirubin; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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