Document Detail

Rhabdomyolysis and Peroneal Nerve Compression Associated with Thyroid Hormone Withdrawal in the Setting of Remnant Ablation: A Review of the Literature.
MedLine Citation:
PMID:  21454241     Owner:  NLM     Status:  Publisher    
Objective: To report a case of nontraumatic common peroneal nerve compression associated with hypothyroidism-induced rhabdomyolysis in a diabetic patient prepared for remnant ablation following thyroidectomy for differentiated thyroid carcinoma. We reviewed the putative mechanisms whereby hypothyroidism is associated with severe myopathy, neural injury and acute compartment syndrome.Methods: We performed a review of the English language literature on PubMed database using the terms hypothyroidism, muscle disease, hypothyroid myopathy, rhabdomyolysis, compression neuropathy and acute compartment syndrome.Results: Myopathy occurs frequently among patients with overt hypothyroidism, however, severe myoneural injury appears to be precipitated or accompanied by co-morbid conditions. Focal peroneal neuropathy may be related to hypothyroidism-induced extrinsic compression from severe myopathy and soft tissue swelling in a narrowed fascial compartment.Conclusion: Severe short-term iatrogenic hypothyroidism may lead to severe myopathy and compression nerve injury in patients with underlying diabetic neuropathy. We recommend avoiding thyroid hormone withdrawal for purposes of remnant ablation among patients with pre-existing diabetic neuropathy.
Abdulaziz Ramadhan; Ronald Schondorf; Michael Tamilia
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-25
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  -     ISSN:  1934-2403     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-4-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-21     Citation Subset:  -    
Division of Endocrinology and Metabolism, Department of Medicine, Jewish General Hospital, McGill University, Montreal Quebec.
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