Document Detail

Rh-immunization by pregnancy: results of a survey and their relevance to prophylactic therapy.
MedLine Citation:
PMID:  4176073     Owner:  NLM     Status:  MEDLINE    
A series of Rh-negative primiparae has been studied in order to gain further insight into the process of immunization by pregnancy. The distribution of foetal cell counts in blood samples taken after delivery was determined for 2,029 mothers giving birth to ABO-compatible babies and for 417 mothers with ABO-incompatible babies.A total of 760 mothers were tested for the development of Rh antibodies six months after the delivery of an ABO-compatible Rh-positive baby and 236 were further followed up through a second Rh-positive pregnancy. The incidence of anti-D six months after delivery is estimated to be 8.5%, and there is evidence of a direct relation between the count of foetal cells after delivery and the risk of developing antibodies. A further 8.5% of mothers were estimated to develop anti-D by the end of the second pregnancy, and it is postulated that these individuals had been primed by the first pregnancy. There is some evidence that the larger stimuli of Rh-positive blood in the first pregnancy are more likely to result in overt antibody formation, while the smaller stimuli are more likely to prime, antibodies not being detected until a second stimulus occurs during the second pregnancy.These findings are relevant to the programme for preventing Rh-immunization by injecting anti-D gammaglobulin.
J C Woodrow; W T Donohoe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  4     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1968 Oct 
Date Detail:
Created Date:  1968-11-25     Completed Date:  1968-11-25     Revised Date:  2012-05-09    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  AIM; IM    
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MeSH Terms
ABO Blood-Group System
Antibodies / analysis
Antibody Formation
Blood Cell Count
Delivery, Obstetric
Erythroblastosis, Fetal / etiology,  immunology,  prevention & control*
Fetomaternal Transfusion / complications
Pregnancy Complications, Hematologic / immunology*,  prevention & control
Rh-Hr Blood-Group System*
Sex Factors
gamma-Globulins / therapeutic use
Reg. No./Substance:
0/ABO Blood-Group System; 0/Antibodies; 0/Rh-Hr Blood-Group System; 0/gamma-Globulins; EC

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