Document Detail

Rh D foeto-maternal alloimmunization prophylaxis with anti-D immunoglobulins reviewed in the era of foetal RHD genotyping.
MedLine Citation:
PMID:  19670558     Owner:  NLM     Status:  MEDLINE    
In Belgium, prevention of anti-D immunization is currently based on systematic postnatal prophylaxis associated with targeted antenatal injection in high-risk situations of foeto-maternal haemorrhage.The failures of prevention are mainly due to the non-respect of established guidelines for RhlG prophylaxis, and to spontaneous undetected foetal-maternal haemorrhages without any obvious cause during the third trimester of pregnancy. In order to reduce the rate of residual post-pregnancy anti-D immunization, several countries decided to associate the classical prophylaxis to a routine antenatal anti-D prophylaxis (RAADP) during the 28th or 29th week of gestation. Since a few years, the foetal RHD genotyping in maternal plasma enables us to limit the antenatal prophylaxis only to those D- women carrying a D+ foetus. This paper deals with: the advantages of an antenatal prevention in the light of non-invasive foetal RHD genotyping, the rules rendering prevention protocols efficient whatever the algorithm applied, and the recommended immuno-haematology follow-up of women who received RhlG.
J-M Minon; Ch Gerard; J-P Schaaps; J-M Foidart
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta clinica Belgica     Volume:  64     ISSN:  1784-3286     ISO Abbreviation:  Acta Clin Belg     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-08-12     Completed Date:  2009-10-08     Revised Date:  2014-03-18    
Medline Journal Info:
Nlm Unique ID:  0370306     Medline TA:  Acta Clin Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  195-202     Citation Subset:  IM    
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MeSH Terms
Blood Grouping and Crossmatching
Erythroblastosis, Fetal / prevention & control*
Immunologic Factors / therapeutic use*
Isoantibodies / therapeutic use*
Prenatal Care*
Reg. No./Substance:
0/Immunologic Factors; 0/Isoantibodies; 0/RHO(D) antibody

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