| Reye's syndrome: current concepts. | |
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MedLine Citation:
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PMID: 3542776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite greater than 23 years of study, an incomplete understanding of the etiology, epidemiology and pathogenesis of Reye's syndrome persists. Better understanding of the disease has been hampered by the lack of a good animal model on which hypotheses of its pathogenesis could be tested. Human studies indicate that a primary mitochondrial injury may lead to complex metabolic disturbances that produce the observed pathophysiology. Specific directions regarding avenues for future research should pursue two lines: a good animal model still needs to be developed in which the biochemical and morphologic alterations identified in Reye's syndrome are duplicated. This model should include an antecedent viral illness but may not require aspirin exposure as an essential ingredient. With the identification of a satisfactory model, specific questions about the roles of environmental toxins or medications may be answered. Study of noncomatose cases of Reye's syndrome should continue. The specific emphasis should be to delineate what factors (NH3, free fatty acids and dicarboxylic acids) may be implicated in the pathogenesis of the CNS disease with the hopes of devising strategies for more effective treatment of encephalopathy and its attendant morbidity and mortality. |
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Authors:
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J E Heubi; J C Partin; J S Partin; W K Schubert |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 7 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1987 Jan-Feb |
Date Detail:
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Created Date: 1987-03-24 Completed Date: 1987-03-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 155-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Ammonia / blood Animals Child Disease Models, Animal Hepatic Encephalopathy / metabolism Humans Liver / metabolism Metabolism, Inborn Errors / complications Reye Syndrome / epidemiology, etiology, metabolism* Salicylates / adverse effects Toxins, Biological / adverse effects United States |
| Grant Support | |
ID/Acronym/Agency:
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RR-00123/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Salicylates; 0/Toxins, Biological; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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