Document Detail


Reye's and Reye's-like syndromes.
MedLine Citation:
PMID:  18711704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The review reports various questions about Reye's syndrome and Reye's-like syndromes. Although there is a significant decrease in the classic Reye's syndrome cases, because of the reduced employment of salicylates in children (salicylate seems to be the most important inducing factor of the syndrome in paediatric subjects affected by viral infection), the problem is still of interest considering the presence of different Reye's-like forms. All these pathological situations are associated with various aetiologic or predisposing causes that are examined in the text. Particular attention is placed on metabolic disorders, especially of fatty acid metabolism, and also of one amino acid. In fact, a latent form can also be the basis of possible biochemical disturbances induced by various exogenous factors such as viral infections, particularly of the respiratory tract (more rarely of bacterial aetiology), or produced by microbial toxins, or by chemical substances, including some therapeutic drugs. A full discussion of biochemical mechanisms of salicylate-induced Reye's syndrome is reported. Finally a possible diagnostic differentiation from classic Reye's syndrome and Reye's-like syndromes plus therapeutic prospects are briefly examined.
Authors:
Agostino Pugliese; Tiziana Beltramo; Donato Torre
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  26     ISSN:  1099-0844     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2009-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  England    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 John Wiley & Sons, Ltd.
Affiliation:
Department of Medical and Surgical Sciences, Teaching of Clinical Virology in Post Doctoral Schools of Medicine, University of Turin, "Amedeo di Savoia" Hospital, Turin, Italy. agostino.pugliese@unito.it
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MeSH Terms
Descriptor/Qualifier:
Aspirin / adverse effects
Humans
Metabolic Diseases / complications
Reye Syndrome / diagnosis,  etiology,  pathology*,  therapy
Chemical
Reg. No./Substance:
50-78-2/Aspirin

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