Document Detail


Rewiring the injured CNS: lessons from the optic nerve.
MedLine Citation:
PMID:  17610877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The optic nerve offers a number of advantages for investigating mechanisms that govern axon regeneration in the CNS. Although mature retinal ganglion cells (RGCs) normally show no ability to regenerate injured axons through the optic nerve, this situation can be partially reversed by inducing an inflammatory response in the eye. The secretion of a previously unknown growth factor, oncomodulin, along with co-factors, causes RGCs to undergo dramatic changes in gene expression and regenerate lengthy axons into the highly myelinated optic nerve. By themselves, strategies that counteract inhibitory signals associated with myelin and the glial scar are insufficient to promote extensive regeneration in this system. However, combinatorial treatments that activate neurons' intrinsic growth state and overcome inhibitory signals result in dramatic axon regeneration in vivo. Because of the ease of introducing trophic factors, soluble receptors, drugs, or viruses expressing any gene or small interfering RNA of interest into RGCs, this system is ideal for identifying intracellular signaling pathways, transcriptional cascades, and ligand-receptor interactions that enable axon regeneration to occur in the CNS.
Authors:
Larry Benowitz; Yuqin Yin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-06-07
Journal Detail:
Title:  Experimental neurology     Volume:  209     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-04-11     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-98     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Central Nervous System Diseases / physiopathology*
Intercellular Signaling Peptides and Proteins / physiology
Macrophages / physiology
Myelin Proteins / metabolism
Nerve Regeneration / physiology*
Optic Nerve / physiology*
Grant Support
ID/Acronym/Agency:
EY 05690/EY/NEI NIH HHS; P30 HD 018655/HD/NICHD NIH HHS; R01 EY005690/EY/NEI NIH HHS; R01 EY005690-28/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Myelin Proteins
Comments/Corrections

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