| Rewiring Chemistry: Algorithmic Discovery and Experimental Validation of One-Pot Reactions in the Network of Organic Chemistry. | |
| | |
MedLine Citation:
|
PMID: 22807071 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Computational algorithms are used to identify sequences of reactions that can be performed in one pot. These predictions are based on over 86 000 chemical criteria by which the putative sequences are evaluated. The "raw" algorithmic output is then validated experimentally by performing multiple two-, three-, and even four-step sequences. These sequences "rewire" synthetic pathways around popular and/or important small molecules. |
| | |
Authors:
|
Chris M Gothard; Siowling Soh; Nosheen A Gothard; Bartlomiej Kowalczyk; Yanhu Wei; Bilge Baytekin; Bartosz A Grzybowski |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-13 |
Journal Detail:
|
Title: Angewandte Chemie (International ed. in English) Volume: - ISSN: 1521-3773 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Department of Chemistry, Northwestern University, 2145 Sheridan Rd., Evanston, IL 60208 (USA) http://dysa.northwestern.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantitative assessment of foot structure in rheumatoid arthritis by a foot digitizer allows detecti...
Next Document: Nearly Temperature-Independent Threshold for Amplified Spontaneous Emission in Colloidal CdSe/CdS Qu...