Document Detail

Rewards in practice from chrono-meta-analyses 'recycling' heart rate, ectopy, ischemia and blood pressure information.
MedLine Citation:
PMID:  9350598     Owner:  NLM     Status:  MEDLINE    
Previously published average curves of heart rate and duration of ischemia in patients with coronary artery disease, studied while on placebo or on treatment with either atenolol or diltiazem, are re-analysed for the assessment of about-daily (circadian) and about-weekly (circaseptan) changes in these variables and of any treatment effect on rhythm characteristics. In addition to circadians, a circaseptan pattern characterizes the duration of ischemia in all three aforementioned study stages. Both drugs decrease the duration of ischemia, atenolol, but not diltiazem, also affects the circadian amplitude and acrophase of this variable. A circaseptan pattern is also found for heart rate on placebo and on treatment with atenolol, but not with diltiazem. Both drugs lower heart rate and the circadian amplitude and 24-h standard deviation of heart rate, atenolol much more markedly than diltiazem. Circadian and circaseptan rhythm characteristics and their alterations with treatment serve to optimize treatment by timing its administration. Chronobiologic surveillance of variables that are being readily monitored as-one-goes by modern implantable devices can also serve for the validation of the effectiveness of drug and electrical therapy. Rhythm alterations, in turn, can provide the earliest warnings of an elevated disease risk and lead to an improved diagnosis.
F Halberg; G Cornélissen; K Otsuka; Y Watanabe; M A Wood; C R Lambert; R Zaslavskaya; D Gubin; E Yuryevna Petukhova; P Delmore; E Bakken
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of medical engineering & technology     Volume:  21     ISSN:  0309-1902     ISO Abbreviation:  J Med Eng Technol     Publication Date:    1997 Sep-Oct
Date Detail:
Created Date:  1997-12-22     Completed Date:  1997-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7702125     Medline TA:  J Med Eng Technol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  174-84     Citation Subset:  IM    
Chronobiology Laboratories, University of Minnesota, Minneapolis, USA.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Atenolol / therapeutic use*
Blood Pressure / drug effects*
Calcium Channel Blockers / therapeutic use*
Cardiac Complexes, Premature / drug therapy*
Circadian Rhythm / drug effects
Coronary Disease / diagnosis,  drug therapy*
Diltiazem / therapeutic use*
Electrocardiography, Ambulatory / drug effects*
Heart Rate / drug effects*
Hemodynamics / drug effects
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Calcium Channel Blockers; 29122-68-7/Atenolol; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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