Document Detail


Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions.
MedLine Citation:
PMID:  19195646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Increased attribution of incentive salience to neutral or aversive stimuli might be associated with dysfunction of neuronal processing of positive and negative reinforcement and contribute to the formation of delusions in schizophrenia.
METHODS: Fifteen unmedicated patients with schizophrenia (8 drug-naive and 7 drug-free for at least 3 months) and 15 age- and gender-matched healthy control participants underwent functional magnetic resonance imaging to investigate neural responses to feedback of (successful vs. unsuccessful) monetary gain or avoidance of loss. Functional connectivity was assessed between the medial prefrontal cortex (MPFC) and ventral striatum (VS), brain areas known to be activated by feedback of reward and loss.
RESULTS: Responses to negative outcome in reward trials (omission of expected reward) were exaggerated in the MPFC of patients with schizophrenia. In contrast, schizophrenia patients showed reduced neural responses to successful versus unsuccessful avoidance of loss in the VS. Increased severity of delusions in schizophrenia patients was associated with a decrease in MPFC activation elicited by successful versus unsuccessful avoidance of loss. Functional connectivity between the MPFC and the VS was reduced in patients with schizophrenia compared with healthy control subjects.
CONCLUSIONS: These findings demonstrate a differential impairment of-and reduced connectivity between--VS and MPFC during processing of reward and loss-avoidance in drug-free patients with schizophrenia. Moreover, our results provide a link between the formation of delusions and the neural processing of aversive outcomes.
Authors:
Florian Schlagenhauf; Philipp Sterzer; Katharina Schmack; Martina Ballmaier; Michael Rapp; Jana Wrase; Georg Juckel; Jürgen Gallinat; Andreas Heinz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-05
Journal Detail:
Title:  Biological psychiatry     Volume:  65     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-08-20     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1032-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Delusions / psychology*
Feedback, Psychological / physiology*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Motivation
Neostriatum / physiology
Prefrontal Cortex / physiology
Reaction Time / physiology
Reward*
Schizophrenic Psychology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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