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Reward abnormalities among women with full and subthreshold bulimia nervosa: A functional magnetic resonance imaging study.
MedLine Citation:
PMID:  21058348     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: To test the hypothesis that women with full and subthreshold bulimia nervosa show abnormal neural activation in response to food intake and anticipated food intake relative to healthy control women. METHOD:: Females with and without full/subthreshold bulimia nervosa recruited from the community (N = 26) underwent functional magnetic resonance imaging (fMRI) during receipt and anticipated receipt of chocolate milkshake and a tasteless control solution. RESULTS:: Women with bulimia nervosa showed trends for less activation than healthy controls in the right anterior insula in response to anticipated receipt of chocolate milkshake (vs. tasteless solution) and in the left middle frontal gyrus, right posterior insula, right precentral gyrus, and right mid dorsal insula in response to consumptions of milkshake (vs. tasteless solution). DISCUSSION:: Bulimia nervosa may be related to potential hypofunctioning of the brain reward system, which may lead these individuals to binge eat to compensate for this reward deficit, though the hypo-responsivity might be a result of a history of binge eating highly palatable foods. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2010).
Cara Bohon; Eric Stice
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-5
Journal Detail:
Title:  The International journal of eating disorders     Volume:  -     ISSN:  1098-108X     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Psychology, University of Oregon, Eugene, Oregon.
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