| Revolution in mitochondrial medicine. | |
| | |
MedLine Citation:
|
PMID: 10437772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A revolution in chemical pathology occurred about 40 years ago with the discovery of a patient with mitochondrial dysfunction. The field of mitochondrial medicine has experienced explosive growth during the last decade. More than 50 mtDNA mutations and several nuclear gene mutations have been identified in affected patients. The recent development of animal models will continue the revolution in mitochondrial medicine by facilitating in depth studies of the molecular pathogenesis and development of novel drug and gene therapy strategies for mitochondrial dysfunction. As we enter the next millennium, we can expect mitochondrial medicine to remain a dynamic and rapidly developing field. |
| | |
Authors:
|
N G Larsson; R Luft |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: FEBS letters Volume: 455 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1999 Jul |
Date Detail:
|
Created Date: 1999-08-16 Completed Date: 1999-08-16 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 199-202 Citation Subset: IM |
Affiliation:
|
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden. nils-goran.larsson@cmm.ki.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
genetics,
metabolism Animals DNA, Mitochondrial / genetics* Disease Models, Animal Humans Mitochondria / metabolism Mitochondrial Myopathies / genetics*, metabolism, therapy Mutation |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Mitochondrial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in clinic vaccination coverage after institution of measurement and feedback in 4 states and...
Next Document: Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implica...