Document Detail


Revival of the use of botulinum toxin: application in dermatology.
MedLine Citation:
PMID:  10894957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Botulinum toxins (BTXs) comprise a family of neurotoxins designated as types A-G, which are produced by the anerobic bacterium Clostridium botulinum. BTX-A blocks the cholinergic transmission resulting in flaccid paralysis and autonomous nerve dysfunction. It has become a powerful therapeutic tool in a variety of conditions over the last decades. Primarily used in the treatment of strabismus, blepharospasm and hemifacial spasms, BTX has only recently been recognized in dermatology. The use of BTX in dermatology includes the treatment of focal hyperhidrosis, hyperfunctional facial lines as well as paralysis of the anal sphincter in the therapy of anal fissures. The mechanism of action is described and the current literature is reviewed.
Authors:
R Böni; O P Kreyden; G Burg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  200     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2000  
Date Detail:
Created Date:  2000-08-23     Completed Date:  2000-08-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Affiliation:
Department of Dermatology, University Hospital, Zürich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Botulinum Toxins / therapeutic use*
Humans
Skin / drug effects,  pathology
Skin Diseases / drug therapy*
Chemical
Reg. No./Substance:
0/Botulinum Toxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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