| Revisiting the role of IL-2 in autoimmunity. | |
| | |
MedLine Citation:
|
PMID: 20458706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
IL-2 was discovered as a T-cell growth factor that promoted T-cell-dependent immune responses; however, more recent studies suggest that the essential role of IL-2 is to maintain functional Treg and thus control immune responses. These results are leading to new ideas about the potential of IL-2 as a therapeutic strategy in autoimmune diseases. In this issue of the European Journal of Immunology, a study further examines the role of IL-2 in immune regulation and shows for the first time that IL-2 complexes can ameliorate autoantibody-mediated autoimmunity. This commentary examines the current findings in relation to what we already know about IL-2 complexes. |
| | |
Authors:
|
Hans Dooms; Abul K Abbas |
Related Documents
:
|
8748696 - Immunotoxic effects of prolonged dietary exposure of male rats to 2,3,7,8-tetrachlorodi... 3131876 - Interleukin-2: inception, impact, and implications. 10638706 - Cytokine production from murine cd4 and cd8 cells after mannan-muc1 immunization. 10524546 - Effect of beta-agonists on production of cytokines by activated t cells obtained from a... 8748696 - Immunotoxic effects of prolonged dietary exposure of male rats to 2,3,7,8-tetrachlorodi... 19935766 - S100 calgranulins in inflammatory arthritis. |
Publication Detail:
|
Type: Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-14 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1538-40 Citation Subset: IM |
Affiliation:
|
Department of Pathology, University of California, San Francisco, CA 94143-0511, USA. Hans.Dooms@ucsf.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoimmunity / immunology* Humans Interleukin-2 / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AI35297/AI/NIAID NIH HHS; R01 AI073656/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-2 |
| Comments/Corrections | |
Comment On:
|
Eur J Immunol. 2010 Jun;40(6):1577-89
[PMID:
20352624
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel immunoregulatory function for IL-23: Inhibition of IL-12-dependent IFN-? production.
Next Document: Development of a Ruthenium(II) Complex Based Luminescent Probe for Imaging Nitric Oxide Production i...