| Revisiting the function of nuclear scaffold/matrix binding proteins in X chromosome inactivation. | |
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MedLine Citation:
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PMID: 21881412 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mammalian females repress gene expression from one of their two X chromosomes to compensate for the gene dosage difference between females and males, via a process called X chromosome inactivation (XCI). Since the first discovery of XCI 50 years ago, the knowledge of this phenomenon has greatly contributed to a better understanding of the molecular mechanism that controls the epigenetic regulation of gene expression. The key molecule that organizes the chromatin-level repression is an X-linked 17-kb non-coding RNA named Xist. The transcripts of Xist are localized along the entire length of the X chromosome and subsequently recruit a chromatin remodeling complex that introduces the repressive epigenetic modifications. In the present review, we will highlight the recent findings that have illustrated the close relationship between XCI and the structural component of the nucleus called the nuclear scaffold/matrix, with an emphasis on the function of the bona-fide scaffold/matrix-binding protein hnRNP U/SAF-A. |
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Authors:
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Yuko Hasegawa; Shinichi Nakagawa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-01 |
Journal Detail:
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Title: RNA biology Volume: 8 ISSN: 1555-8584 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235328 Medline TA: RNA Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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RNA Biology Laboratory, RIKEN Advanced Research Institute; Wako, Saitama, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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