Document Detail

Revisiting the central dogma in the 21st century.
MedLine Citation:
PMID:  19845625     Owner:  NLM     Status:  MEDLINE    
Since the elaboration of the central dogma of molecular biology, our understanding of cell function and genome action has benefited from many radical discoveries. The discoveries relate to interactive multimolecular execution of cell processes, the modular organization of macromolecules and genomes, the hierarchical operation of cellular control regimes, and the realization that genetic change fundamentally results from DNA biochemistry. These discoveries contradict atomistic pre-DNA ideas of genome organization and violate the central dogma at multiple points. In place of the earlier mechanistic understanding of genomics, molecular biology has led us to an informatic perspective on the role of the genome. The informatic viewpoint points towards the development of novel concepts about cellular cognition, molecular representations of physiological states, genome system architecture, and the algorithmic nature of genome expression and genome restructuring in evolution.
James A Shapiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1178     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-22     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-28     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science, Chicago, IL 60637, USA.
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MeSH Terms
DNA Transposable Elements / genetics
Evolution, Molecular*
Gene Rearrangement
Molecular Biology
Reg. No./Substance:
0/DNA Transposable Elements

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