Document Detail

Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS.
MedLine Citation:
PMID:  17448587     Owner:  NLM     Status:  MEDLINE    
The lineages of both astrocytes and oligodendrocytes have been popular areas of research in the last decade. The source of these cells in the mature CNS is relevant to the study of the cellular response to CNS injury. A significant amount of evidence exists to suggest that resident precursor cells proliferate and differentiate into mature glial cells that facilitate tissue repair and recovery. Additionally, the re-entry of mature astrocytes into the cell cycle can also contribute to the pool of new astrocytes that are observed following CNS injury. In order to better understand the glial response to injury in the adult CNS we must revisit the astrocyte-oligodendrocyte relationship. Specifically, we argue that there is a common glial precursor cell from which astrocytes and oligodendrocytes differentiate and that the microenvironment surrounding the injury determines the fate of the stimulated precursor cell. Ideally, better understanding the origin of new glial cells in the injured CNS will facilitate the development of therapeutics targeted to alter the glial response in a beneficial way.
Jessica Carmen; Tim Magnus; Riccardo Cassiani-Ingoni; Larry Sherman; Mahendra S Rao; Mark P Mattson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2007-03-18
Journal Detail:
Title:  Progress in neurobiology     Volume:  82     ISSN:  0301-0082     ISO Abbreviation:  Prog. Neurobiol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370121     Medline TA:  Prog Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-62     Citation Subset:  IM    
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA.
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MeSH Terms
Astrocytes / cytology,  physiology*
Brain Injuries / physiopathology*
Cell Differentiation / physiology
Cell Lineage / physiology
Central Nervous System / cytology,  physiology*
Gliosis / physiopathology
Nerve Regeneration / physiology*
Oligodendroglia / cytology,  physiology*
Stem Cells / cytology,  physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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