Document Detail

Revisiting the association between maternal smoking during pregnancy and ADHD.
MedLine Citation:
PMID:  20413131     Owner:  NLM     Status:  In-Process    
OBJECTIVE: Studies examining the relationship between maternal smoking during pregnancy and the development of Attention Deficit Hyperactivity Disorder (ADHD) among offspring have yielded mixed results, with some studies suggesting a strong association and others finding no association. These studies have varied in quality of design and measures. The purpose of this study was to evaluate the association between maternal smoking during pregnancy and offspring ADHD, using detailed prospective smoking data and subsequent follow-up data from the Collaborative Perinatal Project (CPP).
METHOD: Maternal smoking status was collected throughout pregnancy during the original CPP study. Offspring were followed-up in early adulthood and questioned about ADHD symptoms and diagnosis. Logistic regression was used to model the association between maternal smoking during pregnancy and ADHD. Linear and logistic regression were used to examine clinical characteristics and remission rates associated with ADHD in relation to maternal smoking.
RESULTS: No association was found between maternal smoking during pregnancy and offspring ADHD. Further, no differences in age of onset, number of symptoms, or likelihood of remission were found among ADHD subjects with and without a history of maternal smoking during pregnancy.
CONCLUSIONS: These findings do not support the hypothesis that maternal smoking during pregnancy is causally related to ADHD. Ongoing research should continue to strive to identify those environmental or genetic factors that may enhance the impact of maternal smoking on ADHD or that may be associated more clearly with the development and potential prevention of ADHD.
Sarah W Ball; Stephen E Gilman; Eric Mick; Garrett Fitzmaurice; Michael L Ganz; Larry J Seidman; Stephen L Buka
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2010-04-21
Journal Detail:
Title:  Journal of psychiatric research     Volume:  44     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1058-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Grant Support
2T76MC00001//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regulatory T cells increased while IL-1? decreased during antidepressant therapy.
Next Document:  Benthic indicators: From subjectivity to objectivity - Where is the line?