Document Detail


Revisiting the Response Mechanism of Polymeric Membrane Based Heparin Electrodes.
MedLine Citation:
PMID:  23293506     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Potentiometric membrane electrodes that respond to heparin and other polyanions were introduced in the early 1990s. Herein, the mechanism of polymer membrane electrode type heparin sensors is revisited. The extraction/diffusion of heparin is studied via both potentiometric and impedance spectroscopic techniques using a pre-fractionated heparin preparation that contains polyanionic species > 10000 Daltons. The reversal in EMF response using this heparin preparation indicates diffusion of higher MW heparin fragments to the backside of the membrane. Diffusion coefficients are calculated using a novel formula derived from the phase boundary potential model and Fick's second law of diffusion. Impedance spectroscopy is also employed to show that high MW heparin species are extracted and diffuse across the PVC membranes.
Authors:
Andrea K Bell; Lajos Höfler; Mark E Meyerhoff
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-3
Journal Detail:
Title:  Electroanalysis     Volume:  24     ISSN:  1040-0397     ISO Abbreviation:  Electroanalysis     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908702     Medline TA:  Electroanalysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  53-59     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055.
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