Document Detail


Revisiting Langerhans cells in paracoccidioidomycosis: Expression of CD207/langerin in human cutaneous and mucosal lesions.
MedLine Citation:
PMID:  21757025     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate and granulomas. Mucosal lesions presented a higher expression of langerin in lesions with loose granulomas. For the first time we presented the expression of langerin in paracoccidioidomycosis. Positive cells in dermis and corium could represent migrating Langerhans cells or a new subset of langerin+ cells with a role in paracoccidioidomycosis.
Authors:
Carla Pagliari; Elaine Raniero Fernandes; Wellington Luiz Ferreira da Silva; Aline Alves de Lima Silva; Felipe Weisshaupt Stegun; Maria Irma Seixas Duarte; Mirian Nacagami Sotto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Microbes and infection / Institut Pasteur     Volume:  -     ISSN:  1769-714X     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883508     Medline TA:  Microbes Infect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Institut Pasteur. Published by Elsevier SAS. All rights reserved.
Affiliation:
Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Brazil.
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