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Revisiting Immune-based Therapies for Aggressive Follicular Cell-Derived Thyroid Cancers.
MedLine Citation:
PMID:  23317509     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: With our growing understanding of the immune system and mechanisms employed by the tumor to evade destruction, the field of cancer immunotherapy has been revitalized. Concurrent inflammation has long been associated with follicular cell-derived thyroid cancer (FDTC). In the last decade, much research has focused on characterizing the tumor-associated immune response in patients with FDTC. Summary: Mast cells, NK cells, macrophages, dendritic cells, B cells, and T cells have been identified within FDTC-associated immune infiltrate. Collectively, these suggest that the immune response to FDTC is compromised and may even promote tumor progression. A more thorough characterization of the tumor-associated immune response in FDTC may lead to the development of immune-based adjuvant therapies for patients with aggressive disease. Conclusions: Immune-based therapies could provide essential alternatives to patients that cannot be treated surgically, those with recurrent or persistent lymph node metastases, and those with anaplastic thyroid cancer.
Authors:
Jena French
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  -     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Colorado, School of Medicine, Medicine/Endocrinology, 12801 E. 17th Ave, Campus Box 8106, RC1S, 7401D, Aurora, Colorado, United States, 80045, 303-724-3928; jena.french@ucdenver.edu.
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