Document Detail

Activins and related proteins in the establishment of pregnancy.
MedLine Citation:
PMID:  20228378     Owner:  NLM     Status:  MEDLINE    
Activin A and related proteins (inhibins, follistatin [FS], follistatin-related gene [FLRG], endometrial bleeding associated factors [ebaf]) are involved in the complex mechanisms allowing the establishment and the maintenance of pregnancy. As a consequence of ovarian progesterone stimuli, activin A is expressed and secreted by the stromal endometrial cells, which locally induces the decidualization process, a prerequisite for implantation. Moreover, activin A does influence the implantation phase, also enhancing cytotrophoblast differentiation, indirectly, by increasing the expression of other molecules involved in embryo implantation, such as matrix metalloproteinases (MMPs) and leukemia inhibitory factor (LIF). The local derangement of activin A pathway in some pregnancy disorders (incomplete and complete miscarriages, recurrent abortion, and ectopic pregnancy [EP]) further sustains the hypothesis that activin A and its related proteins play a relevant role in the establishment of pregnancy.
Pasquale Florio; Massimo Gabbanini; Lavinia E Borges; Lorella Bonaccorsi; Serena Pinzauti; Fernando M Reis; Paulo Boy Torres; Giuseppe Rago; Pietro Litta; Felice Petraglia
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  17     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-30     Citation Subset:  IM    
Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetrics and Gynecology, University of Siena, Policlinico Le Scotte, Siena, Italy.
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MeSH Terms
Activins / metabolism*
Embryo Implantation / physiology
Follistatin / metabolism*
Inhibins / metabolism*
Left-Right Determination Factors / metabolism*
Leukemia Inhibitory Factor / metabolism
Matrix Metalloproteinases / metabolism
Pregnancy Complications / metabolism*
Progesterone / metabolism
Reg. No./Substance:
0/Follistatin; 0/LEFTY2 protein, human; 0/Left-Right Determination Factors; 0/Leukemia Inhibitory Factor; 104625-48-1/Activins; 57-83-0/Progesterone; 57285-09-3/Inhibins; EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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