| REVIEW TOPIC ON MANAGEMENT OF ENDOCRINE DISEASE Beneficial effect of real-time continuous glucose monitoring system on glycemic control in type 1 diabetic patients: systematic review and meta-analysis of randomized trials. | |
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MedLine Citation:
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PMID: 22096111 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AbstractObjective: Real-time continuous glucose monitoring (RT-CGM) provides detailed information on glucose patterns and trends, thus allowing the patients to manage their diabetes more effectively.Design: The aim of this study was to explore potential beneficial effects of the use of RT-CGM on diabetes management as compared to self blood glucose measurement (SBGM) in patients with type 1 diabetes (T1DM), by means of a systematic review and meta-analysis of randomized controlled trials (RCTs).Methods: MEDLINE, EMBASE and The Cochrane Library were searched through by two independent investigators for RCTs concerning the use of RT-CGM in patients with T1DM. Only studies with a similar insulin regimen in the experimental and in the control group were included in the analysis.Results: Seven RCTs (n=948) met the inclusion criteria. Combined data from all studies showed better HbA1c reduction in subjects using RT-CGM compared with SBGM (MD - 0.25; 95% CI: - 0.34 to - 0.17; p<0.001). Patients treated with insulin pump and RT-CGM had a lower HbA1c level as compared to subjects managed with insulin pump and SBGM (4 RCTs, n=497; MD - 0.26; 95% CI: - 0.43 to - 0.10; p=0.002). The benefits of applying RT-CGM were not associated with an increasing rate of major hypoglycemic episodes. The use of RT-CGM for over 60-70% of time was associated with a significant lowering of HbA1c.Conclusions: RT-CGM is more beneficial than SBGM in reducing HbA1c in patients with type 1 diabetes. Further studies are needed to evaluate the efficacy of this system in pediatric population, especially in very young children. |
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Authors:
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Agnieszka Szypowska; Anna Ramotowska; Katarzyna Dzygalo; Dominik Golicki |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-17 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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A Szypowska, Department of Paediatric, Medical University of Warsaw, Warsaw, 01-184, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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