| Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. | |
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MedLine Citation:
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PMID: 8810036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Individual cells of the budding yeast, Saccharomyces cerevisiae, have a limited division capacity and undergo characteristic changes as they senesce, primarily increasing both their cell size and cell cycle time. The mortality curve for ageing yeast cells can be described by the Gompertz equation, the classical definition for an ageing population. Recent work from several laboratories has demonstrated that genes can determine the yeast lifespan. Studies with the UTH genes have implicated changes in transcriptional silencing during yeast ageing, but the roles of the RAS2, LAG1 and PHB1 genes in regulating yeast longevity are still unclear. What is becoming clearer, however, is that yeast ageing is more than just a bud scar phenomenon. |
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Authors:
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N R Austriaco |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Yeast (Chichester, England) Volume: 12 ISSN: 0749-503X ISO Abbreviation: Yeast Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1997-02-24 Completed Date: 1997-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8607637 Medline TA: Yeast Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 623-30 Citation Subset: IM |
Affiliation:
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Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division
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genetics Genes, Fungal Models, Genetic Mutation Saccharomyces cerevisiae / cytology, genetics*, growth & development* |
| Grant Support | |
ID/Acronym/Agency:
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AG11119/AG/NIA NIH HHS; GM3054/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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