| Review on sobrerol as a muco-modifying drug: experimental data and clinical findings in hypersecretory bronchopulmonary diseases. | |
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MedLine Citation:
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PMID: 3312046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sobrerol is an agent with a terpenic structure used to modify mucus characteristics in patients with hypersecretory bronchopulmonary diseases and this review is aimed at listing and discussing all the scientific evidence on this drug. All the toxicological findings testify its excellent tolerability and very low toxicity. In the pharmacological section of the review the effects of sobrerol on mucus production and its characteristics are discussed together with its effect on experimental models. A number of open clinical trials suggesting a therapeutic potential activity of the drug is examined together with a series of randomized double-blind clinical trials confirming its efficacy in relieving obstructive symptoms in chronic bronchitic patients. |
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Authors:
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P C Braga; L Allegra; R Bossi; R Scuri; C L Castiglioni; S Romandini |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Review |
Journal Detail:
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Title: International journal of clinical pharmacology research Volume: 7 ISSN: 0251-1649 ISO Abbreviation: Int J Clin Pharmacol Res Publication Date: 1987 |
Date Detail:
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Created Date: 1987-12-04 Completed Date: 1987-12-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110183 Medline TA: Int J Clin Pharmacol Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 381-400 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchitis / drug therapy* Bronchoalveolar Lavage Fluid / analysis Clinical Trials as Topic Expectorants / pharmacology, therapeutic use* Humans Mucociliary Clearance / drug effects Mucus / drug effects* Terpenes / pharmacology, therapeutic use* Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Expectorants; 0/Terpenes; 498-71-5/sobrerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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