Document Detail

Review of serologic testing for hepatitis C virus infection and risk of posttransfusion hepatitis C.
MedLine Citation:
PMID:  7513149     Owner:  NLM     Status:  MEDLINE    
Hepatitis C virus (HCV) is a major cause of acute and chronic hepatitis and cirrhosis worldwide. Screening volunteer donors for antibody to HCV (anti-HCV) has reduced the risk of posttransfusion hepatitis C to less than 1.0% per recipient. Virtually all persons with acute HCV infection seem to become chronically infected, and an average of 67% acquire chronic liver disease with persistently elevated liver enzyme values. Among anti-HCV-positive blood donors, 70% to 90% are HCV RNA positive, but less than half have biochemical evidence of liver disease. The extraordinarily high rate of persistent infection observed in humans and the lack of protection against rechallenge with homologous HCV strains demonstrated in experimental studies in chimpanzees suggest that HCV fails to induce an effective neutralizing antibody response. This raises major concerns for the development of effective passive or active immunoprophylaxis against hepatitis C.
M J Alter
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  118     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-25     Completed Date:  1994-05-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-5     Citation Subset:  AIM; IM    
Hepatitis Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.
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MeSH Terms
Blood Donors
Blood Transfusion / adverse effects*
Hepacivirus / immunology*
Hepatitis Antibodies / blood*
Hepatitis C / diagnosis*,  etiology
Hepatitis C Antibodies
Serologic Tests
Reg. No./Substance:
0/Hepatitis Antibodies; 0/Hepatitis C Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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