| Review of the selective COX-2 inhibitors celecoxib and rofecoxib: focus on clinical aspects. | |
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MedLine Citation:
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PMID: 17608990 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The selective cyclooxygenase-2 (COX-2) inhibitors celecoxib and rofecoxib were designed to have similar efficacy but less gastrointestinal toxicity than traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Their efficacy has been demonstrated in the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, postoperative dental pain and dysmenorrhea. These agents produce fewer endoscopic ulcers, symptomatic ulcers and gastrointestinal bleeds than traditional NSAIDs; although the absolute benefit is small and the gastropreserving effect is negated by concurrent use of low-dose aspirin for cardiovascular risk reduction. Nephrotoxicity and hyptertension remain concerns with COX-2 inhibitors, as they are with traditional NSAIDs. COX-2 inhibitors may be safe alternatives to traditional NSAIDs for patients with aspirin-sensitive asthma. |
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Authors:
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Peter S Loewen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: CJEM : Canadian journal of emergency medical care = JCMU : journal canadien de soins médicaux d'urgence Volume: 4 ISSN: 1481-8035 ISO Abbreviation: CJEM Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2007-07-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100893237 Medline TA: CJEM Country: Canada |
Other Details:
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Languages: eng Pagination: 268-75 Citation Subset: - |
Affiliation:
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Internal Medicine, Pharmaceutical Sciences Clinical Service Unit, Vancouver Hospital and Health Sciences Centre, Vancouver, British Colubmia, Canada. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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