Document Detail

Review of the selective COX-2 inhibitors celecoxib and rofecoxib: focus on clinical aspects.
MedLine Citation:
PMID:  17608990     Owner:  NLM     Status:  In-Data-Review    
The selective cyclooxygenase-2 (COX-2) inhibitors celecoxib and rofecoxib were designed to have similar efficacy but less gastrointestinal toxicity than traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Their efficacy has been demonstrated in the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, postoperative dental pain and dysmenorrhea. These agents produce fewer endoscopic ulcers, symptomatic ulcers and gastrointestinal bleeds than traditional NSAIDs; although the absolute benefit is small and the gastropreserving effect is negated by concurrent use of low-dose aspirin for cardiovascular risk reduction. Nephrotoxicity and hyptertension remain concerns with COX-2 inhibitors, as they are with traditional NSAIDs. COX-2 inhibitors may be safe alternatives to traditional NSAIDs for patients with aspirin-sensitive asthma.
Peter S Loewen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  CJEM : Canadian journal of emergency medical care = JCMU : journal canadien de soins médicaux d'urgence     Volume:  4     ISSN:  1481-8035     ISO Abbreviation:  CJEM     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2007-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100893237     Medline TA:  CJEM     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  268-75     Citation Subset:  -    
Internal Medicine, Pharmaceutical Sciences Clinical Service Unit, Vancouver Hospital and Health Sciences Centre, Vancouver, British Colubmia, Canada.
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