| Review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. | |
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MedLine Citation:
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PMID: 20173106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The published, peer-reviewed literature was systematically searched for information on the safety and efficacy of long-term (defined as 28 days or more of continuous therapy) NSAID use in the treatment of canine osteoarthritis. Online databases were reviewed in June 2008 and papers were selected based on their relevance. Fifteen papers were identified and evaluated. Six of seven papers indicated a benefit of long-term treatment over short-term treatment in terms of the reduction of clinical signs or lameness; one study showed no benefit. Fourteen papers evaluated safety with calculated experimental (adverse) event rates (EER) between 0 and 0.31, but there was no correlation between study length and EER (rs=-0.109, P=0.793). The balance of evidence for the efficacy of NSAIDs supports longer-term use of these agents for increased clinical effect. There is no indication in the literature that such an approach is associated with a reduction in safety, although robust data on the safety of long-term NSAID use are lacking in large numbers of dogs. |
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Authors:
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J F Innes; J Clayton; B D X Lascelles |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Veterinary record Volume: 166 ISSN: 2042-7670 ISO Abbreviation: Vet. Rec. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-03-15 Revised Date: 2012-05-10 |
Medline Journal Info:
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Nlm Unique ID: 0031164 Medline TA: Vet Rec Country: England |
Other Details:
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Languages: eng Pagination: 226-30 Citation Subset: IM |
Affiliation:
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Small Animal Teaching Hospital and Musculoskeletal Research Group, Faculty of Veterinary Science, University of Liverpool, Leahurst Campus Neston, Wirral CH64 7TE,. j.f.innes@liv.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / adverse effects, therapeutic use* Dog Diseases / drug therapy* Dogs Drug Administration Schedule / veterinary Osteoarthritis / drug therapy, veterinary* Randomized Controlled Trials as Topic / veterinary Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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