Document Detail

Review: The role of leukaemia inhibitory factor in the establishment of pregnancy.
MedLine Citation:
PMID:  9924186     Owner:  NLM     Status:  MEDLINE    
Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine required for blastocyst implantation in mice. Uterine expression of LIF and that of its receptors has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy. The variations in the reaction of the uterus in preparation for and during implantation are considerable between species and understanding the differences and similarities assists in the interpretation of how this cytokine functions. Recent studies suggest that reduced endometrial LIF contributes to human infertility. Studies also demonstrate a potential role in placentation and fetal development. Thus, LIF has become an important cytokine warranting further investigation in the human. It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled.
D Vogiagis; L A Salamonsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  160     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-90     Citation Subset:  IM    
Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia.
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MeSH Terms
Decidua / physiology
Embryo Implantation / physiology*
Embryonic and Fetal Development / physiology
Growth Inhibitors / physiology*
Leukemia Inhibitory Factor
Lymphokines / physiology*
Mammals / physiology*
Placenta / physiology
Uterus / physiology*
Reg. No./Substance:
0/Growth Inhibitors; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; 0/Lymphokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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