Document Detail


Review of randomized clinical trials of drug-eluting stents for the prevention of in-stent restenosis.
MedLine Citation:
PMID:  16860027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drug-eluting stents (DESs) have shown significant promise at reducing rates of restenosis and subsequent revascularization compared with bare metal stents (BMSs). The purpose of this report is to provide a systematic review of the randomized clinical trials that have evaluated the efficacy and safety of DESs. A total of 28 randomized clinical trials were identified: 21 comparing a DES (sirolimus, paclitaxel, ABT-578, actinomycin, everolimus, or 7-hexanoyltaxol) with a BMS and 7 comparing a DES with another DES (sirolimus vs paclitaxel). Early sirolimus and polymeric paclitaxel studies in low-risk populations demonstrated marked reductions in restenosis according to angiographic and clinical parameters, compared with BMSs. These promising findings led to the more recent evaluations of DESs in higher risk patients in controlled and head-to-head comparisons. In these subsequent trials, sirolimus and paclitaxel DESs continued to exceed the therapeutic potential of BMSs, with a slight but consistent angiographic advantage being observed with the sirolimus DESs.
Authors:
Mark J Eisenberg; Kristin J Konnyu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-06-12
Journal Detail:
Title:  The American journal of cardiology     Volume:  98     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-82     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. meisenberg@epid.jgh.mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Blood Vessel Prosthesis Implantation / instrumentation*
Coated Materials, Biocompatible*
Coronary Restenosis / prevention & control*
Humans
Randomized Controlled Trials as Topic*
Stents*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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