| Review: putative mutagens and carcinogens in foods. II: sorbate and sorbate-nitrite interactions. | |
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MedLine Citation:
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PMID: 6861725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sorbic acid and potassium sorbate are widely used Generally Recognized as Safe (GRAS) food additives with an extremely high (25 mg/kg) acceptable daily intake level. Some children between the ages of 6-24 months may actually ingest this amount. While presently not permitted to be added directly to meat and poultry products in the US, potassium sorbate has been proposed as a preservative for bacon, as an additive in conjunction with nitrite and ascorbate or erythorbate. Sorbate and nitrite form several species of direct-acting mutagens and genotoxic agents when present together at pH's mimicking gastric conditions. Two of the mutagens have been identified as ethylnitrolic acid and 1,4-dinitro-2-methylpyrrole. Mutagen formation is blocked by ascorbate at low pH. Ascorbate at eightfold molar excess leads to inactivation of 1,4-dinitro-2-methylpyrrole near neutral pH but does not destroy the mutagenic nitro compound at low pHs. The combination of sorbate with nitrite represents a potential health risk in the absence of adequate inactivating levels of ascorbate (vitamin C). |
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Authors:
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P E Hartman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Environmental mutagenesis Volume: 5 ISSN: 0192-2521 ISO Abbreviation: Environ Mutagen Publication Date: 1983 |
Date Detail:
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Created Date: 1983-08-11 Completed Date: 1983-08-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7909737 Medline TA: Environ Mutagen Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinogens* Fatty Acids, Unsaturated / toxicity* Food Additives / toxicity* Humans Infant Mutagens* Nitrites / toxicity* Sorbic Acid / toxicity* United States |
| Grant Support | |
ID/Acronym/Agency:
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S07RR07041/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Fatty Acids, Unsaturated; 0/Food Additives; 0/Mutagens; 0/Nitrites; 110-44-1/Sorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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